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Parameter
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Estimated value
|
Ref.
|
Simulations
|
|---|
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n: height of human colon crypt (number of cells in one column of crypt)
|
80
|
[53]
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varied (2–80)
|
|
n: height of murine intestinal crypt (number of cells in one column of crypt)
|
25
|
[33]
| |
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σ: probability of symmetric division
|
16 % in epidermis,
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[4]
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varied (0–1)
|
| |
50 % for intestine, 100 % in germline cells
|
[5, 6]
| |
|
u: mutation rate
|
10−7 in normal cells to 10−2 in the case of chromosomal instability
|
[68]
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u
1 varied from 0.0005 to 0.01
|
| | | |
u
2 varied from 0.0001 to 0.02
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